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EWOG-MDSEuropean Working Group of Myelodysplastic Syndromes (MDS) in Childhood

Original Publications, fulltext in members area
  • Cseh AM, Niemeyer CM, Yoshimi A, Catala A, Fruhwald MC, Hasle H, van den Heuvel-Eibrink MM, Lauten M, De Moerloose B, Smith OP, Bernig T, Gruhn B, Kulozik AE, Metzler M, Olcay L, Suttorp M, Furlan I, Strahm B, Flotho C:
    Therapy with low-dose azacitidine for MDS in children and young adults: a retrospective analysis of the EWOG-MDS study group.
    Brit J Haematol, 2016; 172: 930-936.
  • Helsmoortel HH, Bresolin S, Lammens T, Cavé H, Noellke P, Caye A, Ghazavi F, De Vries A, Hasle H, Labarque V, Masetti R, Stary J, Van den Heuvel-Eibrink MM, Philippé J, Van Roy N, Benoit Y,  Speleman F, Niemeyer CM, Flotho C, Basso G, Te Kronnie G, Van Vlierberghe P, and De Moerloose B:
    LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia
    Blood, 2016; 127 (9): 1163-1172
  • Wlodarski MW, Hirabayashi S, Pastor V, Starý J, Hasle H, Masetti R, Dworzak M, Schmugge M, van den Heuvel-Eibrink M, Ussowicz M, De Moerloose B, Catala A, Smith OP, Sedlacek P, Lankester AC, Zecca M, Bordon V, Matthes-Martin S, Abrahamsson J, Kühl JS, Sykora KW, Albert MH, Przychodzien B, Maciejewski J, Schwarz S, Göhring G, Schlegelberger B, Cseh A, Noellke P, Yoshimi A, Locatelli F, Baumann I, Strahm B, Niemeyer CM:
    Prevalence, clinical characteristics and prognosis of GATA2-related myelodysplastic syndromes (MDS) in children and adolescents.
    Blood, 2016; 127 (11): 1387-1397
  • Cseh A, Niemeyer CM, Yoshimi A, Dworzak M, Hasle H, van den Heuvel-Eibrink MM, Locatelli F, Masetti R, Schmugge M, Groß-Wieltsch U, Candás A, Kulozik AE, Olcay L, Suttorp M, Furlan I, Strahm B, Flotho C:
    Bridging to transplant with azacitidine in juvenile myelomonocytic leukemia: a retrospective analysis of the EWOG-MDS study group.
    Blood. 2015 Apr 2;125(14):2311-3
  • Aalbers, AM, van den Heuvel-Eibrink MM, Baumann I, Beverloo HB, Driessen GJ, Dworzak M, Fischer A, Zecca M, Zwaan CM, van Dongen JJ, Pieters R, Niemeyer CM, van der Velden VH, Langerak AW:
    T-cell receptor Vβ skewing frequently occurs in refractory cytopenia of childhood and is associated with an expansion of effector cytotoxic T-cells: a prospective study by EWOG-MDS.
    Blood Cancer J, 2014; 4:e209
  • Aalbers AM, van der Velden VH, Yoshimi A, Fischer A, Noellke P, Zwaan CM, Baumann I, Beverloo HB, Dworzak M, Hasle H, Locatelli F, De Moerloose B, Gohring G, Schmugge M, Stary J, Zecca M, Langerak AW, van Dongen JJ, Pieters R, Niemeyer CM, van den Heuvel-Eibrink MM:
    The clinical relevance of minor paroxysmal nocturnal hemoglobinuria clones in refractory cytopenia of childhood: a prospective study by EWOG-MDS.
    Leukemia, 2014; 28: 189-192
    .

  • Yoshimi A, Strahm B, Baumann I, Furlan I, Schwarz S, Teigler-Schlegel A, Walther JU, Schlegelberger B, Göhring G, Nöllke P, Führer M, Niemeyer CM:
    Hematopoietic stem cell transplantation in children and young adults with secondary myelodysplastic syndrome and acute myelogenous leukemia after aplastic anemia.
    Biol Blood Marrow Tr, 2014; 20: 421-434.

  • Yoshimi A, van den Heuvel-Eibrink MM, Baumann I, Schwarz S, Simonitsch-Klupp I, de Paepe P, Campr V, Birk Kerndrup G, O' Sullivan M, Devito R, Leguit R, Hernandez M, Dworzak M, de Moerloose B, Stary J, Hasle H, Smith OP, Zecca M, Catala A, Schmugge M, Locatelli F, Fuhrer M, Fischer A, Guderle A, Nollke P, Strahm B, Niemeyer CM:
    Comparison of horse and rabbit anti-thymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood.
    Haematologica J, 2014; 99: 656-663.

  • Aalbers AM, van den Heuvel-Eibrink MM, de Haas V, Te Marvelde JG, de Jong AX, van der Burg M, Dworzak M, Hasle H, Locatelli F, De Moerloose B, Schmugge M, Stary J, Zecca M, Zwaan CM, van de Loosdrecht AA, van Dongen JJ, Niemeyer CM, van der Velden VH:
    Applicability of a reproducible flow cytometry scoring system in the diagnosis of refractory cytopenia of childhood.
    Leukemia, 2013; 27 (9): 1923-1925
    .

  • Flotho C, Vraetz T, Lang P, Niemeyer CM, Strahm B: Successful double umbilical cord blood transplantation for relapsed juvenile myelomonocytic leukemia.
    Leukemia, 2013; 27 (4): 988-989
    .

  • Locatelli F, Crotta A, Ruggeri A, Eapen M, Wagner JE, Macmillan ML, Zecca M, Kurtzberg J, Bonfim C, Vora A, Diaz de Heredia C, Teague L, Stein J, O'Brien TA, Bittencourt H, Madureira A, Strahm B, Peters C, Niemeyer C, Gluckman E, Rocha V:
    Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study.
    Blood, 2013; 122 (12): 2135-2141.

  • Yoshimi A, Niemeyer C, Baumann I, Schwarz-Furlan S, Schindler D, Ebell W, Strahm B:
    High incidence of Fanconi anemia in patients with a morphological picture consistent with refractory cytpenia of childhood.
    Brit J Haematol, 2013; 160 (1): 109-111.

  • Yoshimi A, Niemeyer CM, Fuhrer MM, Strahm B:
    Comparison of the efficacy of rabbit and horse antithymocyte globulin for the treatment of severe aplastic anemia in children.
    Blood, 2013; 121 (5): 860-861
    .

  • Hirabayashi S, Flotho C, Moetter J, Heuser M, Hasle H, Gruhn B, Klingebiel T, Thol F, Schlegelberger B, Baumann I, Strahm B, Stary J, Locatelli F, Zecca M, Bergstraesser E, Dworzak M, van den Heuvel-Eibrink MM, De Moerloose B, Ogawa S, Niemeyer CM, Wlodarski MW
    Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML.
    Blood, 2012, 119(11): e96-9 (link to journal)

  • Irith Baumann, Monika Fuehrer, Sonja Behrendt, Vit Campr, Judit Csomor, Ingrid Furlan, Valerie de Haas, Gitte Kerndrup, Roos J Leguit, Pascale De Paepe, Peter Noellke, Charlotte Niemeyer, Stephan Schwarz
    Morphological differentiation of severe aplastic anaemia from hypocellular refractory cytopenia of childhood: reproducibility of histopathological diagnostic criteria.
    Histopathology 2012 DOI: 10.1111/j.1365-2559.2011.04156.x (link to journal)

  • Olk-Batz C, Poetsch AR, Nöllke P, Claus R, Zucknick M, Sandrock I, Witte T, Strahm B, Hasle H, Zecca M, Stary J, Bergstraesser E, De Moerloose B, Trebo M, van den Heuvel-Eibrink MM, Wojcik D, Locatelli F, Plass C, Niemeyer CM, Flotho C.:
    Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia (JMML) with poor outcome.
    Blood. 2011 May 5;117(18):4871-80. Epub 2011 Mar 15 (link to journal)

  • Strahm B, Nöllke P, Zecca M, Korthof ET, Bierings M, Furlan I, Sedlacek P, Chybicka A, Schmugge M, Bordon V, Peters C, O'Marcaigh A, de Heredia CD, Bergstraesser E, Moerloose BD, van den Heuvel-Eibrink MM, Starý J, Trebo M, Wojcik D, Niemeyer CM, Locatelli F.:
    Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study.
    Leukemia (2011) 25, 455–462 (link to journal)

  • Madureira AB, Eapen M, Locatelli F, Teira P, Zhang MJ, Davies SM, Picardi A, Woolfrey A, Chan KW, Socié G, Vora A, Bertrand Y, Sales-Bonfim CM, Gluckman E, Niemeyer C, Rocha V:
    Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation.
    Leukemia (2011) 25, 449–454 (link to journal)

  • Wlodarski MW, Motter J, Gorr TA, Olk-Batz C, Hasle H, Dworzak M, Niemeyer CM, Flotho C:
    Abnormal promoter DNA methylation in juvenile myelomonocytic leukemia is not caused by mutation in DNMT3A.
    Blood, 2011; 118 (16): 4490-4491 (link to journal)

  • Hasle H, Niemeyer CM.
    Advances in the prognostication and management of advanced MDS in children.
    British Journal of Haematology  2011; 154: 185-195 (link to journal)

  • Göhring G, Michalova K, Beverloo HB, Betts D, Harbott J, Haas OA, Kerndrup G, Sainati L, Bergstraesser E, Hasle H, Stary J, Trebo M, van den Heuvel-Eibrink MM, Zecca M, van Wering ER, Fischer A, Noellke P, Strahm B, Locatelli F, Niemeyer CM, Schlegelberger B.:
    Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome.
    Blood November 11, 2010 vol. 116 no. 19 3766-3769 (link to journal)

  • Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Starý J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML:
    Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.
    Nat Genet. 2010 Sep;42(9):794-800. Epub 2010 Aug 8 (link to journal)

  • Batz C, Hasle H, Bergsträsser E, van den Heuvel-Eibrink MM, Zecca M, Niemeyer CM, Flotho C:
    Does SPRED1 contribute to leukemogenesis in juvenile myelomonocytic leukemia (JMML)?
    Blood. 2010 Mar 25;115(12):2557-8 (link to journal)

  • Flotho C, Batz C, Hasle H, Bergstrasser E, van den Heuvel-Eibrink MM, Zecca M, Niemeyer CM, Zenker M.
    Mutational analysis of SHOC2, a novel gene for Noonan-like syndrome, in JMML.
    Blood 2010; 115: 913 (link to journal)

  • Silvia Bresolin, Marco Zecca, Christian Flotho, Luca Trentin, Andrea Zangrando, Laura Sainati, Jan Stary, Barbara de Moerloose, Henrik Hasle, Charlotte M. Niemeyer, Geertruy te Kronnie, Franco Locatelli, and Giuseppe Basso:
    Gene Expression–Based Classification As an Independent Predictor of Clinical Outcome in Juvenile MyelomonocyticLeukemia.
    JCO, 2010 Mar 10.1200/JCO.2009.24.4426 (link to journal)

  • Mignon L. Loh, Debbie S. Sakai, Christian Flotho, Michelle Kang, Manfred Fliegauf, Sophie Archambeault, Charles G. Mullighan, Leslie Chen, Eva Bergstraesser, Carlos E. Bueso-Ramos, Peter D. Emanuel, Henrik Hasle, Jean-Pierre Issa, Marry M. van den Heuvel-Eibrink, Franco Locatelli, Jan Stary´, Monica Trebo, Marcin Wlodarski, Marco Zecca, Kevin M. Shannon, and Charlotte M. Niemeyer:
    Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.
    Blood. 2009 August 27; 114(9):1859-63 (link to journal)

  • Karow A, Flotho C, Schneider M, Fliegauf M, Niemeyer CM:
    Mutations of the Shwachman-Bodian-Diamond syndrome (SBDS) gene in patients presenting with refractory cytopenia - do we have to screen?
    Haematologica. 2009 Nov 30 (link to journal)

  • Furlan I, Batz C, Flotho C, Mohr B, Lübbert M, Suttorp M, Niemeyer CM:
    Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7.
    Blood. 2009 Mar 19;113(12):2867-8 (link to journal)

  • Flotho C, Kratz CP, Bergstraesser E, Hasle H, Stary J, Trebo M, van den Heuvel-Eibrink MM, Wójcik D, Zecca M, Locatelli F, Niemeyer CM:
    Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations.
    Blood 111(2): 966-967, 2008 (link to journal)

  • de Vries ACH, Stam RW, Kratz CP, Zenker M, Niemeyer CM, van den Heuvel-Eibrink MM:
    Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia.
    Haematologica 92(11): 1557-1560, 2007 (link to journal)

  • Strahm B, Locatelli F, Bader P, Ehlert K, Kremens B, Zintl F, Führer M, Stachel D, Sykora KW, Sedlacek P, Baumann I, Niemeyer CM:
    Reduced intensity conditioning in unrelated donor transplantation for refractory cytopenia in childhood.
    Bone Marrow Transplant. 2007 Aug;40(4):329-33 (link to journal)

  • Starý J, Baumann I, Creutzig U, Harbott J, Michalova K, Niemeyer C.:
    Getting the numbers straight in pediatric MDS: Distribution of subtypes after exclusion of down syndrome.
    Pediatr Blood Cancer Volume 50, Issue 2, 435-436, 2008 Feb (link to journal)

  • Zecca M, Begamaschi G, Bergsträßer E, Danesino C, De Filippi P, Hasle H, Kratz C, Lisini D, Locatelli F, Pession A, Sainati L, Starý J, Trebo M, van den Heuvel-Eibrink M, Wójcik D, Niemeyer CM:
    V617F JAK2 gene mutation is a rare event in juvenile myelomonocytic leukemia.
    Leukemia 21 (2) : 367-369, 2007 (link to journal)

  • Yoshimi A, Baumann I, Führer M, Bergsträsser E, Göbel U, Sykora KW, Klingebiel T, Gross-Wieltsch U, van den Heuvel-Eibrink M, Fischer A, Nöllke P, Niemeyer CM:
    Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia.
    Haematologica. 2007 Mar;92(3):397-400 (link to journal)

  • Hasle H, Alonzo TA, Auvrignon A, Behar C, Chang M, Creutzig U, Fischer A, Forestier E, Fynn A, Haas OA, Harbott J, Harrison CJ, Heerema NA, van den Heuvel-Eibrink MM, Kaspers GJ, Locatelli F, Noellke P, Polychronopoulou S, Ravindranath Y, Razzouk B, Reinhardt D, Savva NN, Stark B, Suciu S, Tsukimoto I, Webb DK, Wojcik D, Woods WG, Zimmermann M, Niemeyer CM, Raimondi SC:
    Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study.
    Blood, Jun 2007; 109: 4641 - 4647 (link to journal)

  • Yoshimi A, Mohamed M, Bierings M, Urban C, Korthof E, Zecca M, Sykora K-W, Duffner U, Trebo M, Matthes´-Martin S, Sedlacek P, Klingebiel T, Lang P, Führer M, Claviez A, Wössmann W, Pession A, Arvidson J, o’Marcaigh AS, van den Heuvel-Eibrink MM, Hasle H, Nöllke P, Locatelli F, Niemeyer CM:
    Second allogeneic hematopoietic stem cell transplantation (HSCT) results in outcome similar to that of first HSCT for patients with juvenile myelomonocytic leukemia.
    Leukemia 21(3): 556-560, 2007 (link to journal)

  • Bergstraesser E, Hasle H, Rogge T, Fischer A, Zimmermann M, Noellke P, Niemeyer CM:
    Treatment of juvenile myelomonocytic leukemia other than hematopoietic stem cell transplantation: a retrospective analysis and definition of response criteria.
    Pediatric Blood & Cancer 49 (5): 629-633, 2007 Oct (link to journal)

  • Ayami Yoshimi, Charlotte M Niemeyer, Viktoria Bohmer, Ulrich Duffner, Brigitte Strahm, Hermann Kreyenberg, Dagmar Dilloo, Felix Zintl, Alexander Claviez, Willi Wössmann, Bernhard Kremens, Wolfgang Holter Dietrich Niethammer, James Beck, Udo Kontny, Peter Nöllke, Thomas Klingebiel, Peter Bader:
    Chimerism analyses and subsequent immunological intervention after stem cell transplantation in patients with juvenile myelomonocytic leukaemia.
    British Journal of Haematology, 2005;129:542-549 (link to journal)

  • Ayami Yoshimi, Peter Bader, Susanne Matthes-Martin, Jan Starý, Peter Sedlacek, Ulrich Duffner, Thomas Klingebiel, Dagmar Dilloo, Wolfgang Holter, Felix Zintl, Bernhard Kremens, Karl-Walter Sykora, Christian Urban, Henrik Hasle, Elisabeth Korthof, Tom Révész, Alexandra Fischer, Peter Nöllke, Franco Locatelli, Charlotte M Niemeyer:
    Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia.
    Leukemia, 2005;19:971-977 (link to journal)

  • Henrik Hasle, Irith Baumann, Eva Bergsträsser, Susanna Fenu, Gabriella Kardos, Gitte Kerndrup, Franco Locatelli, Georg Mann, Tim Rogge, Kirk R. Schultz, Jan Starý, Marry van den Heuvel-Eibrink, Jochen Harbott, Peter Nöllke, Charlotte M. Niemeyer:
    The international prognostic scoring system (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML).
    Leukemia, 2004, 18, pp. 2008-2014 (link to journal)

  • Franco Locatelli, Peter Nöllke, Marco Zecca, Elisabeth Korthof, Edoardo Lanino, Christina Peters, Andrea Pession, Hartmut Kabisch, Cornelio Uderzo, Carmen S Bonfim, Peter Bader, Dagmar Dilloo, Jan Stary, Alexandra Fischer, Tom Revesz, Monika Fuhrer, Henrik Hasle, Monika Trebo, Marry M van den Heuvel-Eibrink, Susanna Fenu, Brigitte Strahm, Giovanna Giorgiani, Mario R Bonora, Ulrich Duffner, and Charlotte M Niemeyer:
    Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial.
    Blood, Sep 2004; 10.1182/blood-2004-05-1944 (link to journal)

  • Gabriela Kardos, Irith Baumann, S. Jane Passmore, Franco Locatelli, Henrik Hasle, Kirk R. Schultz, Jan Starý, Annette Schmitt-Graeff, Alexandra Fischer, Jochen Harbott, Judith M. Chessells, Ian Hann, Susanna Fenu, Angelo Cantú Rajnoldi, Gitte Kerndrup, Elisabeth van Wering, Tim Rogge, Peter Nöllke, Charlotte M. Niemeyer:
    A Refractory Anemia in Childhood: A Retrospective Analysis of 67 Cases with Particular Reference to Monosomy 7.
    Blood, 15 September 2003, Vol. 102, No. 6, pp. 1997-2003 (link to journal)

  • Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, Hählen K, Hasle H, Licht JD, Gelb BD:
    Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.
    Nature Genetics, Published online: 28 April 2003, doi:10.1038/ng1156 (link to journal)

  • Hasle H, Niemeyer CM, Chessells JM, Baumann I, Bennett JM, Kerndrup G, Head DR:
    A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases.
    Leukemia 17(2):277-82, 2003 (link to journal)

  • Hasle H, Aricó M, Biondi A, Cantú Rajnoldi A, Creutzig U, Fenu S, Fonatsch C, Haas OA, Harbott J, Kerndrup G, Mann G, Niemeyer CM, Ptoskova H, Ritter J, Slater R, Stary J, Stollmann-Gibbels B, Testi AM, van Wering ER, and Zimmermann M:
    Myelodysplastic syndrome and acute myeloid leukemia associated with complete or partial monosomy 7.
    Leukemia 13(3):376-385, 1999 (link to journal)

  • Donald Pinkel;, Maurizio Aricò, Andrea Biondi, Ching-Hon Pui;, C.M. Niemeyer, S. Fenu, H. Hasle, G. Mann, J. Stary, and E. van Wering:
    Differentiating Juvenile Myelomonocytic Leukemia From Infectious Disease.
    Blood 91(1): 365-367, 1998 (link to journal)

  • Niemeyer CM, Aricó M, Biondi A, Basso G, Cantú Rajnoldi A, Creutzig U, Haas O, Harbott J, Hasle H, Kerndrup G, Locatelli F, Mann G, Stollmann-Gibbels B, van't Veer-Korthof ET, van Wering E, Zimmermann M:
    Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases.
    Blood 89(10):3534-3543, 1997 (link to journal)

  • Locatelli F, Niemeyer C, Angelucci E, Bender-Götze C, Burdach S, Wolfram E, Friedrich W, Hasle H, Hermann J, Jacobsen N, Klingebiel T, Kremens B, Pession A, Peters C, Schmid HJ, Stary J, Suttorp M, Uderzo C, van't Veer-Korthof ET, Vossen J, Zecca M, Zimmermann M:
    Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on Myelodysplastic Syndrome in Childhood (EWOG-MDS).
    J Clin Oncol 15(2):566-573, 1997 (link to journal)
EWOG-MDS Studycenter

University Hospital
Dep. of Pediatric and Adolescent Medicine

D-79106 Freiburg
Germany

ewog-mds@uniklinik-freiburg.de